#Carbonic acid pka free#

Using the Henderson-Hasselbach equation, how do you determine the concentration of bicarbonate ion in normal blood sample which is pH 7.40. The considerable acid strength of intact carbonic acid indicates that it is an important protonation agent under physiological conditions. The concentration of carbonic acid in normal blood is 0.029 mol/L and the pKa for carbonic acid is 6.1. This establishes H2CO3 as being 0.37 pKa units stronger and about 1 pKa unit weaker, respectively, than the physiologically important lactic and pyruvic acids.

#Carbonic acid pka free#

The pKa of carbonic acid was found to be 3.49 ± 0.05 using both the Marcus and Kiefer-Hynes free energy correlations.

The on-contact PT rates were found to follow the acidity order of the carboxylic acids: the stronger was the acid, the slower was the PT reaction to its conjugate base. The time-dependent diffusion-assisted PT rate was analyzed using the Szabo-Collins-Kimball equation with a radiation boundary condition. The on-contact proton transfer (PT) reaction rate from the optically excited photoacid to the carboxylic bases was derived, with unprecedented precision, from time-correlated single-photon-counting measurements of the fluorescence lifetime of the photoacid in the presence of the proton acceptors. A particular goal is to establish the pKa of carbonic acid H2CO3. Depending on the pH of the solution either DNA or RNA can be extracted.Carbonic, lactic, and pyruvic acids have been generated in aqueous solution by the transient protonation of their corresponding conjugate bases by a tailor-made photoacid, the 6-hydroxy-1-sulfonate pyrene sodium salt molecule. Phenol is a component in liquid–liquid phenol–chloroform extraction technique used in molecular biology for obtaining nucleic acids from tissues or cell culture samples. Phenol is also a versatile precursor to a large collection of drugs, most notably aspirin but also many herbicides and pharmaceutical drugs. Nonionic detergents are produced by alkylation of phenol to give the alkylphenols, e.g., nonylphenol, which are then subjected to ethoxylation. Partial hydrogenation of phenol gives cyclohexanone, a precursor to nylon. Condensation of phenol, alkylphenols, or diphenols with formaldehyde gives phenolic resins, a famous example of which is Bakelite. The calculated p K a values of carbonic acid and formic acid at B3LYP/6-311++G (d, p) and HF/6-311++G (d, p) levels At 298 K, the experimental p K a 1 and p K a 2 for carbonic acid is 6.36, 10.33 separately and the experimental p K a for formic acid is 3.75 17. Also, the pKa value of carbonic acid is 6.36 for the first dissociation equation while it is 4.76 for acetic acid. Condensation with acetone gives bisphenol-A, a key precursor to polycarbonates and epoxide resins. The major uses of phenol, consuming two thirds of its production, involve its conversion to precursors for plastics. Acid-Base Equilibria citric acid (C6H8O7), 7.5 x 10 1.7 x 10 carbonic acid (H2CO3), 4.5 x 10 4.7 x 10 hydrogen sulfide (H2S), 1.0 x 10 1.3 x 10. 8 - 12 it is in equilibrium with the phenolate anion C 6H 5O − (also called phenoxide): C 6 H 5 OH ↽ − − ⇀ C 6 H 5 O − + H + The sodium salt of phenol, sodium phenoxide, is far more water-soluble.

Homogeneous mixtures of phenol and water at phenol to water mass ratios of ~2.6 and higher are possible. Phenol is an organic compound appreciably soluble in water, with about 84.2 g dissolving in 1000 mL (0.895 M). 2.3.1 Hydrolysis of benzenesulfonic acid.